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QuickBooks Error 6189, 816 occurs when trying to access a company file that is either in use or unavailable, often due to multi-user mode issues or file corruption. To fix this, restart both your server and workstations to clear any temporary network glitches. Ensure QuickBooks Desktop is updated by selecting Help > Update QuickBooks Desktop and downloading the latest updates. Use the QuickBooks Tool Hub to run Quick Fix My Program and scan for file-related issues. If the company file is hosted on a server, run QuickBooks Database Server Manager to ensure proper network access. Moving the company file to a local drive can help avoid network conflicts. If the issue persists, renaming the .ND and .TLG files can help reset the network descriptors and transaction logs, as they will regenerate automatically when QuickBooks is reopened. If these steps don't resolve the error, contacting QuickBooks Support may be necessary